The No. 6 ranked Notre Dame Fighting Irish (5-0), led by quarterback Ian Book, meet the Virginia Tech Hokies (3-1), led by quarterback Josh Jackson, in a Week 6 NCAA college football game on Saturday, October 6, 2018 (10/6/18) at Lane Stadium in Blacksburg, Virginia. Click here for Week 6 picks and predictions. Here's what you need to know: Who: Notre Dame vs. Virginia Tech What: NCAA football When: Saturday, Oct. 6, 2018 Where: Lane Stadium, Blacksburg, Va. Time: 8 p.m. Eastern TV: ABC Livestream: WatchESPN Line: Notre Dame -5.5 Week 6 picks and predictions Week 6 picks and predictions College football Week 6 picks, predictions, point spreads, betting lines. Will Kyler Murray and Oklahoma be able to remain undefeated against rival Texas? Will Notre Dame keep rolling toward the College Football Playoff? Who will win between Air Force and Navy in the first leg of the competition for the Commander-in-Chief's Trophy? Things to watch in the Atlantic Coast Conference in Week 6: GAME OF THE WEEK